What is one change made to the Constitution?

The correct choice regarding a change made to the Constitution is the prohibition of alcohol, known as the 18th Amendment. This amendment, ratified in 1919, made it illegal to manufacture, sell, or transport alcoholic beverages in the United States, marking a significant social and legal shift aimed at reducing alcohol consumption and its associated social problems. The era of Prohibition lasted until the 21st Amendment repealed this change in 1933.

The other options, while related to significant historical issues, reflect amendments or key changes that were not enacted in the same manner or context. Gender equality has been a topic of debate and has influenced gender-related amendments, yet there is no specific amendment solely dedicated to gender equality in the Constitution as it currently stands. Though the voting age was lowered to 18 through the 26th Amendment, which was ratified in 1971, the change is different from the immediate and absolute prohibition of alcohol. The direct election of senators, established by the 17th Amendment, altered how senators were chosen but did not involve the explicit prohibition of a societal practice like alcohol consumption. Thus, the prohibition of alcohol stands out as a significant constitutional change.